Article-Journal

P-Rex1, a PtdIns(3,4,5)P3- and Gβγ-Regulated Guanine-Nucleotide Exchange Factor for Rac
Heidi C. E. Welch, W. John Coadwell, Christian D. Ellson, G. John Ferguson, Simon R. Andrews, Hediye Erdjument-Bromage, Paul Tempst, Phillip T. Hawkins, Len R. Stephens
Cite DOI URL
PI 3-kinase
Sonja Krugmann, Heidi Welch
Cite DOI URL
Expression of azurophil and specific granule proteins during differentiation of NB4 cells in neutrophils
Neutrophils contain several populations of secretory granules with characteristic sets of proteins. Granule proteins are sorted into …
C. Grégoire, H. Welch, C. Astarie-Dequeker, I. Maridonneau-Parini
Cite DOI
Protein kinase B and rac are activated in parallel within a phosphatidylinositide 3OH-kinase-controlled signaling pathway
The GTPase Rac and the protein kinase B (PKB) are downstream targets of phosphatidylinositide 3OH-kinase in platelet-derived growth …
H. Welch, A. Eguinoa, L. R. Stephens, P. T. Hawkins
Cite DOI
Signalling via phosphoinositide 3OH kinases
P T Hawkins, H Welch, A McGregor, A Eguinoa, S Gobert, S Krugmann, K Anderson, D Stokoe, L Stephens
Cite DOI URL
Lyn and Fgr are activated in distinct membrane fractions of human granulocytic cells
We have previously shown that the src-family protein-tyrosine kinase Hck is localized on the azurophil granules of human granulocytes, …
H. Welch, I. Maridonneau-Parini
Cite DOI
Hck Is Activated by Opsonized Zymosan and A23187 in Distinct Subcellular Fractions of Human Granulocytes
Regulation of neutrophil responses is known to involve tyrosine phosphorylation. Hck, a major neutrophil protein-tyrosine kinase, …
H. Welch, I. Maridonneau-Parini
Cite DOI
Nonreceptor Protein-Tyrosine Kinases in Neutrophil Activation
Nonreceptor protein-tyrosine kinases are involved in the regulation of almost all neutrophil responses such as adhesion, chemotaxis, …
H. Welch, C. Mauran, I. Maridonneau-Parini
Cite DOI
The src-family protein-tyrosine kinase p59hck is located on the secretory granules in human neutrophils and translocates towards the phagosome during cell activation
The src-family protein-tyrosine kinase p59hck is mainly expressed in neutrophils; however, its functional role in these cells is …
H. Möhn, V. Le Cabec, S. Fischer, I. Maridonneau-Parini
Cite DOI
The Small GTP-Binding Protein rac Is Not Recruited to the Plasma Membrane upon NADPH Oxidase Activation in Human Neutrophils
Superoxide generation by phagocytic cells requires assembly of the enzymatic complex NADPH oxidase, consisting of membranous and …
V. Lecabec, H. Mohn, G. Gacon, I. Maridonneauparini
Cite DOI URL