Article-Journal

Heidi Welch

P-Rex2 regulates Purkinje cell dendrite morphology and motor coordination

The small GTPase Rac controls cell morphology, gene expression, and reactive oxygen species formation. Manipulations of Rac activity …

Sarah Donald, Trevor Humby, Ian Fyfe, Anne Segonds-Pichon, Simon A. Walker, Simon R. Andrews, W. John Coadwell, Piers Emson, Lawrence S. Wilkinson, Heidi C. E. Welch

Membrane translocation of P-Rex1 is mediated by G protein betagamma subunits and phosphoinositide 3-kinase

P-Rex1 is a guanine-nucleotide exchange factor (GEF) for the small GTPase Rac that is directly activated by the betagamma subunits of …

Mark A. Barber, Sarah Donald, Sylvia Thelen, Karen E. Anderson, Marcus Thelen, Heidi C. E. Welch

Gβγs and the Ras binding domain of p110γ are both important regulators of PI3Kγ signalling in neutrophils: Nature Cell Biology

Through their ability to regulate production of the key lipid messenger PtdIns(3,4,5)P3, the class I phosphatidylinositol-3-OH kinases …

Sabine Suire, Alison M. Condliffe, G. John Ferguson, Chris D. Ellson, Hervé Guillou, Keith Davidson, Heidi Welch, John Coadwell, Martin Turner, Edwin R. Chilvers, Phillip T. Hawkins, Len Stephens

PI3K and RAC signalling in leukocyte and cancer cell migration

Leukocytes and amoeboid-stage cancer cells migrate in a similar manner. Key signalling molecules regulating leukocyte and cancer cell …

Mark A. Barber, Heidi C. E. Welch

Purification of P-Rex1 from neutrophils and nucleotide exchange assay

The P-Rex family of guanine-nucleotide exchange factors (GEFs) are activators of the small GTPase Rac (Donald et al., 2004; Rosenfeldt …

Kirsti Hill, Heidi C. E. Welch

Regulation of P-Rex1 by phosphatidylinositol (3,4,5)-trisphosphate and Gbetagamma subunits

P-Rex1 is a guanine-nucleotide exchange factor (GEF) for the small GTPase Rac. We have investigated here the mechanisms of stimulation …

Kirsti Hill, Sonja Krugmann, Simon R. Andrews, W. John Coadwell, Peter Finan, Heidi C. E. Welch, Phillip T. Hawkins, Len R. Stephens

P-Rex1 Regulates Neutrophil Function

Rac GTPases regulate cytoskeletal structure, gene expression, and reactive oxygen species (ROS) production [1, 2]. Rac2-deficient …

Heidi CE Welch, Alison M. Condliffe, Laura J. Milne, G. John Ferguson, Kirsti Hill, Louise MC Webb, Klaus Okkenhaug, W. John Coadwell, Simon R. Andrews, Marcus Thelen, Gareth E. Jones, Phillip T. Hawkins, Len R. Stephens

P-Rex2, a new guanine-nucleotide exchange factor for Rac

We have identified a new guanine-nucleotide exchange factor, P-Rex2, and cloned it from human skeletal muscle and brain libraries. It …

Sarah Donald, Kirsti Hill, Charlotte Lecureuil, Romain Barnouin, Sonja Krugmann, W. John Coadwell, Simon R. Andrews, Simon A. Walker, Phillip T. Hawkins, Len R. Stephens, Heidi C. E. Welch

Phosphoinositide 3‐kinase‐dependent activation of Rac

The monomeric GTPase Rac and the lipid kinase phosphoinositide 3-kinase (PI3K) are intracellular signalling enzymes that each regulate …

Heidi C.E. Welch, W.John Coadwell, Len R. Stephens, Phillip T. Hawkins