Article-Journal

P-Rex1 Regulates Neutrophil Function

Rac GTPases regulate cytoskeletal structure, gene expression, and reactive oxygen species (ROS) production [1, 2]. Rac2-deficient …

Heidi CE Welch, Alison M. Condliffe, Laura J. Milne, G. John Ferguson, Kirsti Hill, Louise MC Webb, Klaus Okkenhaug, W. John Coadwell, Simon R. Andrews, Marcus Thelen, Gareth E. Jones, Phillip T. Hawkins, Len R. Stephens

P-Rex2, a new guanine-nucleotide exchange factor for Rac

We have identified a new guanine-nucleotide exchange factor, P-Rex2, and cloned it from human skeletal muscle and brain libraries. It …

Sarah Donald, Kirsti Hill, Charlotte Lecureuil, Romain Barnouin, Sonja Krugmann, W. John Coadwell, Simon R. Andrews, Simon A. Walker, Phillip T. Hawkins, Len R. Stephens, Heidi C. E. Welch

Phosphoinositide 3‐kinase‐dependent activation of Rac

The monomeric GTPase Rac and the lipid kinase phosphoinositide 3-kinase (PI3K) are intracellular signalling enzymes that each regulate …

Heidi C.E. Welch, W.John Coadwell, Len R. Stephens, Phillip T. Hawkins

P-Rex1, a PtdIns(3,4,5)P3- and Gβγ-Regulated Guanine-Nucleotide Exchange Factor for Rac

Heidi C. E. Welch, W. John Coadwell, Christian D. Ellson, G. John Ferguson, Simon R. Andrews, Hediye Erdjument-Bromage, Paul Tempst, Phillip T. Hawkins, Len R. Stephens

PI 3-kinase

Sonja Krugmann, Heidi Welch

Expression of azurophil and specific granule proteins during differentiation of NB4 cells in neutrophils

Neutrophils contain several populations of secretory granules with characteristic sets of proteins. Granule proteins are sorted into …

C. Grégoire, H. Welch, C. Astarie-Dequeker, I. Maridonneau-Parini

Protein kinase B and rac are activated in parallel within a phosphatidylinositide 3OH-kinase-controlled signaling pathway

The GTPase Rac and the protein kinase B (PKB) are downstream targets of phosphatidylinositide 3OH-kinase in platelet-derived growth …

H. Welch, A. Eguinoa, L. R. Stephens, P. T. Hawkins

Signalling via phosphoinositide 3OH kinases

P T Hawkins, H Welch, A McGregor, A Eguinoa, S Gobert, S Krugmann, K Anderson, D Stokoe, L Stephens

Lyn and Fgr are activated in distinct membrane fractions of human granulocytic cells

We have previously shown that the src-family protein-tyrosine kinase Hck is localized on the azurophil granules of human granulocytes, …

H. Welch, I. Maridonneau-Parini

Hck Is Activated by Opsonized Zymosan and A23187 in Distinct Subcellular Fractions of Human Granulocytes

Regulation of neutrophil responses is known to involve tyrosine phosphorylation. Hck, a major neutrophil protein-tyrosine kinase, …

H. Welch, I. Maridonneau-Parini