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The dynamics of Rho GTPase signaling and implications for targeting cancer and the tumor microenvironment
Numerous large scale genomics studies have demonstrated that cancer is a molecularly heterogeneous disease, characterized by acquired …
Marina Pajic, David Herrmann, Claire Vennin, James Rw Conway, Venessa T. Chin, Anna-Karin E. Johnsson, Heidi CE Welch, Paul Timpson
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A Rac1-Independent Role for P-Rex1 in Melanoblasts
Colin R. Lindsay, Ang Li, William Faller, Brad Ozanne, Heidi Welch, Laura M. Machesky, Owen J. Sansom
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P-Rex and Vav Rac-GEFs in platelets control leukocyte recruitment to sites of inflammation
The small GTPase Rac is required for neutrophil recruitment during inflammation, but its guanine-nucleotide exchange factor (GEF) …
Dingxin Pan, Richard T. Amison, Yanira Riffo-Vasquez, Domenico Spina, Simon J. Cleary, Michael J. Wakelam, Clive P. Page, Simon C. Pitchford, HeidiCE Welch
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P-Rex1 directly activates RhoG to regulate GPCR-driven Rac signalling and actin polarity in neutrophils
G-protein-coupled receptors (GPCRs) regulate the organisation of the actin cytoskeleton by activating the Rac subfamily of small …
George Damoulakis, Laure Gambardella, Kent L. Rossman, Campbell D. Lawson, Karen E. Anderson, Yoshinori Fukui, Heidi C. Welch, Channing J. Der, Len R. Stephens, Phillip T. Hawkins
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The Rac-FRET mouse reveals tight spatiotemporal control of Rac activity in primary cells and tissues
The small G protein family Rac has numerous regulators that integrate extracellular signals into tight spatiotemporal maps of its …
Anna-Karin E Johnsson, Yanfeng Dai, Max Nobis, Martin J Baker, Ewan J McGhee, Simon Walker, Juliane P Schwarz, Shereen Kadir, Jennifer P Morton, Kevin B Myant, David J Huels, Anne Segonds-Pichon, Owen J Sansom, Kurt I Anderson, Paul Timpson, Heidi C E Welch
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Integrin activation by P-Rex1 is required for selectin-mediated slow leukocyte rolling and intravascular crawling
Integrin activation is essential for the function of leukocytes. Impaired integrin activation on leukocytes is the hallmark of the …
Jan M. Herter, Jan Rossaint, Helena Block, Heidi Welch, Alexander Zarbock
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P-Rex1 cooperates with PDGFRβ to drive cellular migration in 3D microenvironments
Expression of the Rac-guanine nucleotide exchange factor (RacGEF), P-Rex1 is a key determinant of progression to metastasis in a number …
Andrew D. Campbell, Samuel Lawn, Lynn C. McGarry, Heidi C. Welch, Bradford W. Ozanne, Jim C. Norman
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The guanine-nucleotide-exchange factor P-Rex1 is activated by protein phosphatase 1α
P-Rex1 is a GEF (guanine-nucleotide-exchange factor) for the small G-protein Rac that is activated by PIP3 (phosphatidylinositol …
Mark a Barber, Annick Hendrickx, Monique Beullens, Hugo Ceulemans, David Oxley, Sylvia Thelen, Marcus Thelen, Mathieu Bollen, Heidi C E Welch
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P-Rex1 is required for efficient melanoblast migration and melanoma metastasis
Metastases are the major cause of death from melanoma, a skin cancer that has the fastest rising incidence of any malignancy in the …
Colin R. Lindsay, Samuel Lawn, Andrew D. Campbell, William J. Faller, Florian Rambow, Richard L. Mort, Paul Timpson, Ang Li, Patrizia Cammareri, Rachel A. Ridgway, Jennifer P. Morton, Brendan Doyle, Shauna Hegarty, Mairin Rafferty, Ian G. Murphy, Enda W. McDermott, Kieran Sheahan, Katherine Pedone, Alexander J. Finn, Pamela A. Groben, Nancy E. Thomas, Honglin Hao, Craig Carson, Jim C. Norman, Laura M. Machesky, William M. Gallagher, Ian J. Jackson, Leon Van Kempen, Friedrich Beermann, Channing Der, Lionel Larue, Heidi C. Welch, Brad W. Ozanne, Owen J. Sansom
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Ca2+-dependent monomer and dimer formation switches CAPRI Protein between Ras GTPase-activating protein (GAP) and RapGAP activities
CAPRI is a member of the GAP1 family of GTPase-activating proteins (GAPs) for small G proteins. It is known to function as an amplitude …
Yanfeng Dai, Simon A. Walker, Edwin De Vet, Simon Cook, Heidi C. E. Welch, Peter J. Lockyer
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