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Rho Family GTPases and Rho GEFs in Glucose Homeostasis
Dysregulation of glucose homeostasis leading to metabolic syndrome and type 2 diabetes is the cause of an increasing world health …
Polly A. Machin, Elpida Tsonou, David C. Hornigold, Heidi C. E. Welch
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PtdIns(3,4,5)P3-dependent Rac exchanger 1 (P-Rex1) promotes mammary tumor initiation and metastasis
The Rac-GEF, P-Rex1, activates Rac1 signaling downstream of G protein-coupled receptors and PI3K. Increased P-Rex1 expression promotes …
Nuthasuda Srijakotre, Heng-Jia Liu, Max Nobis, Joey Man, Hon Yan Kelvin Yip, Antonella Papa, Helen E. Abud, Kurt I. Anderson, Heidi C. E. Welch, Tony Tiganis, Paul Timpson, Catriona A. McLean, Lisa M. Ooms, Christina A. Mitchell
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Rac-GTPases and Rac-GEFs in neutrophil adhesion, migration and recruitment
Rac-GTPases and their Rac-GEF activators play important roles in the recruitment and host defence functions of neutrophils. These …
Chiara Pantarelli, Heidi C. E. Welch
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Removing physiological motion from intravital and clinical functional imaging data
Intravital microscopy can provide unique insights into the function of biological processes in a native context. However, physiological …
Sean C. Warren, Max Nobis, Astrid Magenau, Yousuf H. Mohammed, David Herrmann, Imogen Moran, Claire Vennin, James Rw Conway, Pauline Mélénec, Thomas R. Cox, Yingxiao Wang, Jennifer P. Morton, Heidi CE Welch, Douglas Strathdee, Kurt I. Anderson, Tri Giang Phan, Michael S. Roberts, Paul Timpson
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A RhoA-FRET Biosensor Mouse for Intravital Imaging in Normal Tissue Homeostasis and Disease Contexts
The small GTPase RhoA is involved in a variety of fundamental processes in normal tissue. Spatiotemporal control of RhoA is thought to …
Max Nobis, David Herrmann, Sean C. Warren, Shereen Kadir, Wilfred Leung, Monica Killen, Astrid Magenau, David Stevenson, Morghan C. Lucas, Nadine Reischmann, Claire Vennin, James Rw Conway, Alice Boulghourjian, Anaiis Zaratzian, Andrew M. Law, David Gallego-Ortega, Christopher J. Ormandy, Stacey N. Walters, Shane T. Grey, Jacqueline Bailey, Tatyana Chtanova, Julian MW Quinn, Paul A. Baldock, Peter I. Croucher, Juliane P. Schwarz, Agata Mrowinska, Lei Zhang, Herbert Herzog, Andrius Masedunskas, Edna C. Hardeman, Peter W. Gunning, Gonzalo Del Monte-Nieto, Richard P. Harvey, Michael S. Samuel, Marina Pajic, Ewan J. McGhee, Anna-Karin E. Johnsson, Owen J. Sansom, Heidi CE Welch, Jennifer P. Morton, Douglas Strathdee, Kurt I. Anderson, Paul Timpson
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Platelets in neutrophil recruitment to sites of inflammation
PURPOSE OF REVIEWThis review describes the essential roles of platelets in neutrophil recruitment from the bloodstream into inflamed …
Simon Pitchford, Dingxin Pan, Heidi CE Welch
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Norbin Stimulates the Catalytic Activity and Plasma Membrane Localization of the Guanine-Nucleotide Exchange Factor P-Rex1
P-Rex1 is a guanine-nucleotide exchange factor (GEF) that activates the small G protein (GTPase) Rac1 to control Rac1-dependent …
Dingxin Pan, Mark A. Barber, Kirsti Hornigold, Martin J. Baker, Judit M. Toth, David Oxley, Heidi CE Welch
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Small GTPases and their guanine-nucleotide exchange factors and GTPase-activating proteins in neutrophil recruitment
Purpose of reviewThe review describes the roles of Rho- and Rap-guanosine triphosphatases (GTPases) and of their activators, …
Martin J Baker, Dingxin Pan, Heidi C E Welch
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Truncating PREX2 mutations activate its GEF activity and alter gene expression regulation in NRAS-mutant melanoma
PREX2 (phosphatidylinositol-3,4,5-triphosphate-dependent Rac-exchange factor 2) is a PTEN (phosphatase and tensin homolog deleted on …
Yonathan Lissanu Deribe, Yanxia Shi, Kunal Rai, Luigi Nezi, Samir B. Amin, Chia-Chin Wu, Kadir C. Akdemir, Mozhdeh Mahdavi, Qian Peng, Qing Edward Chang, Kirsti Hornigold, Stefan T. Arold, Heidi C. E. Welch, Levi A. Garraway, Lynda Chin
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Regulation and function of P-Rex family Rac-GEFs
The P-Rex family are Dbl-type guanine-nucleotide exchange factors for Rac family small G proteins. They are distinguished from other …
Heidi CE Welch
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