Article-Journal | Heidi Welch Consultinghttps://heidiwelchconsulting.com/publication-type/article-journal/Article-JournalHugo Blox Builder (https://hugoblox.com)en-usWed, 01 Nov 2023 00:00:00 +0000https://heidiwelchconsulting.com/media/icon_hu81414f66b0b845984b024077f7bc24ad_71818_512x512_fill_lanczos_center_3.pngArticle-Journalhttps://heidiwelchconsulting.com/publication-type/article-journal/The Rac-GEF Tiam1 controls integrin-dependent neutrophil responseshttps://heidiwelchconsulting.com/publication/journal-article/hornigold-rac-gef-2023/Wed, 01 Nov 2023 00:00:00 +0000https://heidiwelchconsulting.com/publication/journal-article/hornigold-rac-gef-2023/The GPCR adaptor protein Norbin regulates S1PR1 trafficking and the morphology, cell cycle and survival of PC12 cellshttps://heidiwelchconsulting.com/publication/journal-article/johansen-gpcr-2023/Sun, 01 Oct 2023 00:00:00 +0000https://heidiwelchconsulting.com/publication/journal-article/johansen-gpcr-2023/Functions and mechanisms of the GPCR adaptor protein Norbinhttps://heidiwelchconsulting.com/publication/journal-article/chetwynd-functions-2023/Tue, 01 Aug 2023 00:00:00 +0000https://heidiwelchconsulting.com/publication/journal-article/chetwynd-functions-2023/Dock2 generates characteristic spatiotemporal patterns of Rac activity to regulate neutrophil polarisation, migration and phagocytosishttps://heidiwelchconsulting.com/publication/journal-article/machin-dock-2-2023/Sun, 01 Jan 2023 00:00:00 +0000https://heidiwelchconsulting.com/publication/journal-article/machin-dock-2-2023/Age-related decline in the resistance of mice to bacterial infection and in LPS/TLR4 pathway-dependent neutrophil responseshttps://heidiwelchconsulting.com/publication/journal-article/hornigold-age-related-2022/Sat, 01 Jan 2022 00:00:00 +0000https://heidiwelchconsulting.com/publication/journal-article/hornigold-age-related-2022/Behavioural immune landscapes of inflammationhttps://heidiwelchconsulting.com/publication/journal-article/crainiciuc-behavioural-2022/Sat, 01 Jan 2022 00:00:00 +0000https://heidiwelchconsulting.com/publication/journal-article/crainiciuc-behavioural-2022/Small-molecule inhibitors of P-Rex guanine-nucleotide exchange factorshttps://heidiwelchconsulting.com/publication/journal-article/lawson-small-molecule-2022/Sat, 01 Jan 2022 00:00:00 +0000https://heidiwelchconsulting.com/publication/journal-article/lawson-small-molecule-2022/Optimizing metastatic-cascade-dependent Rac1 targeting in breast cancer: Guidance using optical window intravital FRET imaginghttps://heidiwelchconsulting.com/publication/journal-article/floerchinger-optimizing-2021/Wed, 01 Sep 2021 00:00:00 +0000https://heidiwelchconsulting.com/publication/journal-article/floerchinger-optimizing-2021/P-Rex1 Controls Sphingosine 1-Phosphate Receptor Signalling, Morphology, and Cell-Cycle Progression in Neuronal Cellshttps://heidiwelchconsulting.com/publication/journal-article/hampson-p-rex-1-2021/Wed, 01 Sep 2021 00:00:00 +0000https://heidiwelchconsulting.com/publication/journal-article/hampson-p-rex-1-2021/The GPCR adaptor protein norbin suppresses the neutrophil-mediated immunity of mice to pneumococcal infectionhttps://heidiwelchconsulting.com/publication/journal-article/pantarelli-gpcr-2021/Sun, 01 Aug 2021 00:00:00 +0000https://heidiwelchconsulting.com/publication/journal-article/pantarelli-gpcr-2021/Rho Family GTPases and Rho GEFs in Glucose Homeostasishttps://heidiwelchconsulting.com/publication/journal-article/machin-rho-2021/Thu, 01 Apr 2021 00:00:00 +0000https://heidiwelchconsulting.com/publication/journal-article/machin-rho-2021/PtdIns(3,4,5)P3-dependent Rac exchanger 1 (P-Rex1) promotes mammary tumor initiation and metastasishttps://heidiwelchconsulting.com/publication/journal-article/srijakotre-ptdins-345-p-3-dependent-2020/Sun, 01 Nov 2020 00:00:00 +0000https://heidiwelchconsulting.com/publication/journal-article/srijakotre-ptdins-345-p-3-dependent-2020/Rac-GTPases and Rac-GEFs in neutrophil adhesion, migration and recruitmenthttps://heidiwelchconsulting.com/publication/journal-article/pantarelli-rac-gtpases-2018/Thu, 01 Nov 2018 00:00:00 +0000https://heidiwelchconsulting.com/publication/journal-article/pantarelli-rac-gtpases-2018/Removing physiological motion from intravital and clinical functional imaging datahttps://heidiwelchconsulting.com/publication/journal-article/warren-removing-2018/Sun, 01 Jul 2018 00:00:00 +0000https://heidiwelchconsulting.com/publication/journal-article/warren-removing-2018/A RhoA-FRET Biosensor Mouse for Intravital Imaging in Normal Tissue Homeostasis and Disease Contextshttps://heidiwelchconsulting.com/publication/journal-article/nobis-rhoa-fret-2017/Sun, 01 Jan 2017 00:00:00 +0000https://heidiwelchconsulting.com/publication/journal-article/nobis-rhoa-fret-2017/Platelets in neutrophil recruitment to sites of inflammationhttps://heidiwelchconsulting.com/publication/journal-article/pitchford-platelets-2017/Sun, 01 Jan 2017 00:00:00 +0000https://heidiwelchconsulting.com/publication/journal-article/pitchford-platelets-2017/Norbin Stimulates the Catalytic Activity and Plasma Membrane Localization of the Guanine-Nucleotide Exchange Factor P-Rex1https://heidiwelchconsulting.com/publication/journal-article/pan-norbin-2016/Fri, 01 Jan 2016 00:00:00 +0000https://heidiwelchconsulting.com/publication/journal-article/pan-norbin-2016/Small GTPases and their guanine-nucleotide exchange factors and GTPase-activating proteins in neutrophil recruitmenthttps://heidiwelchconsulting.com/publication/journal-article/baker-small-2016/Fri, 01 Jan 2016 00:00:00 +0000https://heidiwelchconsulting.com/publication/journal-article/baker-small-2016/Truncating PREX2 mutations activate its GEF activity and alter gene expression regulation in NRAS-mutant melanomahttps://heidiwelchconsulting.com/publication/journal-article/deribe-truncating-2016/Fri, 01 Jan 2016 00:00:00 +0000https://heidiwelchconsulting.com/publication/journal-article/deribe-truncating-2016/Regulation and function of P-Rex family Rac-GEFshttps://heidiwelchconsulting.com/publication/journal-article/welch-regulation-nodate/Fri, 26 Jun 2015 00:00:00 +0000https://heidiwelchconsulting.com/publication/journal-article/welch-regulation-nodate/The dynamics of Rho GTPase signaling and implications for targeting cancer and the tumor microenvironmenthttps://heidiwelchconsulting.com/publication/journal-article/pajic-dynamics-nodate/Tue, 23 Jun 2015 00:00:00 +0000https://heidiwelchconsulting.com/publication/journal-article/pajic-dynamics-nodate/A Rac1-Independent Role for P-Rex1 in Melanoblastshttps://heidiwelchconsulting.com/publication/journal-article/lindsay-rac-1-independent-2015/Thu, 01 Jan 2015 00:00:00 +0000https://heidiwelchconsulting.com/publication/journal-article/lindsay-rac-1-independent-2015/P-Rex and Vav Rac-GEFs in platelets control leukocyte recruitment to sites of inflammationhttps://heidiwelchconsulting.com/publication/journal-article/pan-p-rex-2015/Thu, 01 Jan 2015 00:00:00 +0000https://heidiwelchconsulting.com/publication/journal-article/pan-p-rex-2015/P-Rex1 directly activates RhoG to regulate GPCR-driven Rac signalling and actin polarity in neutrophilshttps://heidiwelchconsulting.com/publication/journal-article/damoulakis-p-rex-1-2014/Sun, 01 Jun 2014 00:00:00 +0000https://heidiwelchconsulting.com/publication/journal-article/damoulakis-p-rex-1-2014/The Rac-FRET mouse reveals tight spatiotemporal control of Rac activity in primary cells and tissueshttps://heidiwelchconsulting.com/publication/journal-article/johnsson-rac-fret-2014/Sat, 01 Mar 2014 00:00:00 +0000https://heidiwelchconsulting.com/publication/journal-article/johnsson-rac-fret-2014/Integrin activation by P-Rex1 is required for selectin-mediated slow leukocyte rolling and intravascular crawlinghttps://heidiwelchconsulting.com/publication/journal-article/herter-integrin-2013/Tue, 01 Jan 2013 00:00:00 +0000https://heidiwelchconsulting.com/publication/journal-article/herter-integrin-2013/P-Rex1 cooperates with PDGFRβ to drive cellular migration in 3D microenvironmentshttps://heidiwelchconsulting.com/publication/journal-article/campbell-p-rex-1-2013/Tue, 01 Jan 2013 00:00:00 +0000https://heidiwelchconsulting.com/publication/journal-article/campbell-p-rex-1-2013/The guanine-nucleotide-exchange factor P-Rex1 is activated by protein phosphatase 1αhttps://heidiwelchconsulting.com/publication/journal-article/barber-guanine-nucleotide-exchange-2012/Sun, 01 Apr 2012 00:00:00 +0000https://heidiwelchconsulting.com/publication/journal-article/barber-guanine-nucleotide-exchange-2012/P-Rex1 is required for efficient melanoblast migration and melanoma metastasishttps://heidiwelchconsulting.com/publication/journal-article/lindsay-p-rex-1-2011/Tue, 01 Nov 2011 00:00:00 +0000https://heidiwelchconsulting.com/publication/journal-article/lindsay-p-rex-1-2011/Ca2+-dependent monomer and dimer formation switches CAPRI Protein between Ras GTPase-activating protein (GAP) and RapGAP activitieshttps://heidiwelchconsulting.com/publication/journal-article/dai-ca-2-dependent-2011/Wed, 01 Jun 2011 00:00:00 +0000https://heidiwelchconsulting.com/publication/journal-article/dai-ca-2-dependent-2011/P-Rex1 and Vav1 cooperate in the regulation of formyl-methionyl-leucyl-phenylalanine-dependent neutrophil responseshttps://heidiwelchconsulting.com/publication/journal-article/lawson-p-rex-1-2011/Tue, 01 Feb 2011 00:00:00 +0000https://heidiwelchconsulting.com/publication/journal-article/lawson-p-rex-1-2011/Characterization of the Rac guanine nucleotide exchange factor P-Rex1 in plateletshttps://heidiwelchconsulting.com/publication/journal-article/aslan-characterization-2011/Sat, 01 Jan 2011 00:00:00 +0000https://heidiwelchconsulting.com/publication/journal-article/aslan-characterization-2011/Control of cerebellar long-term potentiation by P-Rex-family guanine-nucleotide exchange factors and phosphoinositide 3-kinasehttps://heidiwelchconsulting.com/publication/journal-article/jackson-control-2010/Fri, 01 Jan 2010 00:00:00 +0000https://heidiwelchconsulting.com/publication/journal-article/jackson-control-2010/Role of GEFs in Diseasehttps://heidiwelchconsulting.com/publication/journal-article/welch-role-2008/Tue, 01 Apr 2008 00:00:00 +0000https://heidiwelchconsulting.com/publication/journal-article/welch-role-2008/P-Rex2 regulates Purkinje cell dendrite morphology and motor coordinationhttps://heidiwelchconsulting.com/publication/journal-article/donald-p-rex-2-2008/Sat, 01 Mar 2008 00:00:00 +0000https://heidiwelchconsulting.com/publication/journal-article/donald-p-rex-2-2008/Membrane translocation of P-Rex1 is mediated by G protein betagamma subunits and phosphoinositide 3-kinasehttps://heidiwelchconsulting.com/publication/journal-article/barber-membrane-2007/Mon, 01 Oct 2007 00:00:00 +0000https://heidiwelchconsulting.com/publication/journal-article/barber-membrane-2007/Gβγs and the Ras binding domain of p110γ are both important regulators of PI3Kγ signalling in neutrophils: Nature Cell Biologyhttps://heidiwelchconsulting.com/publication/journal-article/suire-gs-2006/Wed, 01 Nov 2006 00:00:00 +0000https://heidiwelchconsulting.com/publication/journal-article/suire-gs-2006/PI3K and RAC signalling in leukocyte and cancer cell migrationhttps://heidiwelchconsulting.com/publication/journal-article/barber-pi-3-k-2006/Mon, 01 May 2006 00:00:00 +0000https://heidiwelchconsulting.com/publication/journal-article/barber-pi-3-k-2006/Purification of P-Rex1 from neutrophils and nucleotide exchange assayhttps://heidiwelchconsulting.com/publication/journal-article/hill-purification-2006/Sun, 01 Jan 2006 00:00:00 +0000https://heidiwelchconsulting.com/publication/journal-article/hill-purification-2006/Regulation of P-Rex1 by phosphatidylinositol (3,4,5)-trisphosphate and Gbetagamma subunitshttps://heidiwelchconsulting.com/publication/journal-article/hill-regulation-2005/Tue, 01 Feb 2005 00:00:00 +0000https://heidiwelchconsulting.com/publication/journal-article/hill-regulation-2005/P-Rex1 Regulates Neutrophil Functionhttps://heidiwelchconsulting.com/publication/journal-article/welch-p-rex-1-2005/Sat, 01 Jan 2005 00:00:00 +0000https://heidiwelchconsulting.com/publication/journal-article/welch-p-rex-1-2005/P-Rex2, a new guanine-nucleotide exchange factor for Rachttps://heidiwelchconsulting.com/publication/journal-article/donald-p-rex-2-2004/Sun, 01 Aug 2004 00:00:00 +0000https://heidiwelchconsulting.com/publication/journal-article/donald-p-rex-2-2004/Phosphoinositide 3‐kinase‐dependent activation of Rachttps://heidiwelchconsulting.com/publication/journal-article/welch-phosphoinositide-2003/Tue, 01 Jul 2003 00:00:00 +0000https://heidiwelchconsulting.com/publication/journal-article/welch-phosphoinositide-2003/P-Rex1, a PtdIns(3,4,5)P3- and Gβγ-Regulated Guanine-Nucleotide Exchange Factor for Rachttps://heidiwelchconsulting.com/publication/journal-article/welch-p-rex-1-2002/Fri, 01 Mar 2002 00:00:00 +0000https://heidiwelchconsulting.com/publication/journal-article/welch-p-rex-1-2002/PI 3-kinasehttps://heidiwelchconsulting.com/publication/journal-article/krugmann-pi-1998/Sun, 01 Nov 1998 00:00:00 +0000https://heidiwelchconsulting.com/publication/journal-article/krugmann-pi-1998/Expression of azurophil and specific granule proteins during differentiation of NB4 cells in neutrophilshttps://heidiwelchconsulting.com/publication/journal-article/gregoire-expression-1998/Fri, 01 May 1998 00:00:00 +0000https://heidiwelchconsulting.com/publication/journal-article/gregoire-expression-1998/Protein kinase B and rac are activated in parallel within a phosphatidylinositide 3OH-kinase-controlled signaling pathwayhttps://heidiwelchconsulting.com/publication/journal-article/welch-protein-1998/Fri, 01 May 1998 00:00:00 +0000https://heidiwelchconsulting.com/publication/journal-article/welch-protein-1998/Signalling via phosphoinositide 3OH kinaseshttps://heidiwelchconsulting.com/publication/journal-article/hawkins-signalling-1997/Sat, 01 Nov 1997 00:00:00 +0000https://heidiwelchconsulting.com/publication/journal-article/hawkins-signalling-1997/Lyn and Fgr are activated in distinct membrane fractions of human granulocytic cellshttps://heidiwelchconsulting.com/publication/journal-article/welch-lyn-1997/Wed, 01 Oct 1997 00:00:00 +0000https://heidiwelchconsulting.com/publication/journal-article/welch-lyn-1997/Hck Is Activated by Opsonized Zymosan and A23187 in Distinct Subcellular Fractions of Human Granulocyteshttps://heidiwelchconsulting.com/publication/journal-article/welch-hck-1997/Wed, 01 Jan 1997 00:00:00 +0000https://heidiwelchconsulting.com/publication/journal-article/welch-hck-1997/Nonreceptor Protein-Tyrosine Kinases in Neutrophil Activationhttps://heidiwelchconsulting.com/publication/journal-article/welch-nonreceptor-1996/Sat, 01 Jun 1996 00:00:00 +0000https://heidiwelchconsulting.com/publication/journal-article/welch-nonreceptor-1996/The src-family protein-tyrosine kinase p59hck is located on the secretory granules in human neutrophils and translocates towards the phagosome during cell activationhttps://heidiwelchconsulting.com/publication/journal-article/mohn-src-family-1995/Sun, 01 Jan 1995 00:00:00 +0000https://heidiwelchconsulting.com/publication/journal-article/mohn-src-family-1995/The Small GTP-Binding Protein rac Is Not Recruited to the Plasma Membrane upon NADPH Oxidase Activation in Human Neutrophilshttps://heidiwelchconsulting.com/publication/journal-article/lecabec-small-1994/Tue, 01 Feb 1994 00:00:00 +0000https://heidiwelchconsulting.com/publication/journal-article/lecabec-small-1994/Substrate specificity of neutral phospholipase D from rat brain studied by selective labeling of endogenous synaptic membrane phospholipids in vitrohttps://heidiwelchconsulting.com/publication/journal-article/mohn-substrate-1992/Mon, 01 Jun 1992 00:00:00 +0000https://heidiwelchconsulting.com/publication/journal-article/mohn-substrate-1992/A neutral phospholipase D activity from rat brain synaptic plasma membranes. Identification and partial characterizationhttps://heidiwelchconsulting.com/publication/journal-article/chalifa-neutral-1990/Mon, 01 Oct 1990 00:00:00 +0000https://heidiwelchconsulting.com/publication/journal-article/chalifa-neutral-1990/