Article-Journal

P-Rex Rac-GEFs

P-Rex1 and P-Rex2 are Rac-activating GEFs that integrate PI3K and GPCR signals to control immune responses, GPCR trafficking, …

Heidi C. E. Welch

P-Rex1 limits glucose clearance and suppresses hepatocyte glucose uptake and mitochondrial metabolism independently of its Rac-GEF activity

This paper shows that P-Rex1 limits glucose clearance and suppresses hepatocyte glucose uptake and mitochondrial metabolism through a …

Julia Y. Chu, Elpida Tsonou, Polly A. Machin, Kirsty MacLellan-Gibson, Anna G. Roberts, Stephen A. Chetwynd, Adam T. McCormack, John C. Stephens, Elisa Benetti, Gemma K. Kinsella, David Baker, David C. Hornigold, Heidi C. E. Welch

P-Rex1 limits the agonist-induced internalization of GPCRs independently of its Rac-GEF activity

This study shows that P-Rex1 also regulates GPCR trafficking by limiting agonist-stimulated internalization independently of its …

Martin J. Baker, Elizabeth Hampson, Priota Islam, Ruben Pelaez Moral, Eve A. Maunders, Kirsti Hornigold, Elpida Tsonou, Angeliki Malliri, David C. Hornigold, Roderick E. Hubbard, Andrew J. Massey, Heidi C. E. Welch

P-Rex1 controls phagocytosis and the killing of bacteria by murine neutrophils independently of its catalytic activity

Using catalytic-dead and knockout mouse models, this study shows that P-Rex1 supports neutrophil migration, ROS production, and NET …

Priota Islam, Julia Y. Chu, Stephen A. Chetwynd, Rachael Walker, Phillip T. Hawkins, Heidi C. E. Welch

P-Rex2 suppresses glucose uptake into liver and skeletal muscle through different adaptor functions

Elpida Tsonou, Julia Y. Chu, Polly A. Machin, Anna G. Roberts, Anne Segonds-Pichon, David Baker, David C. Hornigold, Heidi C. E. Welch

Aspirin prevents metastasis by limiting platelet TXA2 suppression of T cell immunity

Jie Yang, Yumi Yamashita-Kanemaru, Benjamin I. Morris, Annalisa Contursi, Daniel Trajkovski, Jingru Xu, Ilinca Patrascan, Jayme Benson, Alexander C. Evans, Alberto G. Conti, Aws Al-Deka, Layla Dahmani, Adnan Avdic-Belltheus, Baojie Zhang, Hanneke Okkenhaug, Sarah K. Whiteside, Charlotte J. Imianowski, Alexander J. Wesolowski, Louise v. Webb, Simone Puccio, Stefania Tacconelli, Annalisa Bruno, Sara Di Berardino, Alessandra De Michele, Heidi C. E. Welch, I-Shing Yu, Shu-Wha Lin, Suman Mitra, Enrico Lugli, Louise Van Der Weyden, Klaus Okkenhaug, Kourosh Saeb-Parsy, Paola Patrignani, David J. Adams, Rahul Roychoudhuri

Targeting the PREX2/RAC1/PI3Kβ Signaling Axis Confers Sensitivity to Clinically Relevant Therapeutic Approaches in Melanoma

Catriona A. Ford, Dana Koludrovic, Patricia P. Centeno, Mona Foth, Elpida Tsonou, Nikola Vlahov, Nathalie Sphyris, Kathryn Gilroy, Courtney Bull, Colin Nixon, Bryan Serrels, Alison F. Munro, John C. Dawson, Neil O. Carragher, Valeria Pavet, David C. Hornigold, Philip D. Dunne, Julian Downward, Heidi C. E. Welch, Simon T. Barry, Owen J. Sansom, Andrew D. Campbell

The Rac-GEF Tiam1 controls integrin-dependent neutrophil responses

textlessptextgreaterRac GTPases are required for neutrophil adhesion and migration, and for the neutrophil effector responses that kill …

Kirsti Hornigold, Martin J. Baker, Polly A. Machin, Stephen A. Chetwynd, Anna-Karin Johnsson, Chiara Pantarelli, Priota Islam, Melanie Stammers, Laraine Crossland, David Oxley, Hanneke Okkenhaug, Simon Walker, Rachael Walker, Anne Segonds-Pichon, Yoshinori Fukui, Angeliki Malliri, Heidi C. E. Welch

The GPCR adaptor protein Norbin regulates S1PR1 trafficking and the morphology, cell cycle and survival of PC12 cells

Norbin is an adaptor protein that binds numerous G protein-coupled receptors (GPCRs), is highly expressed in neurons, and is essential …

Valdemar B. I. Johansen, Elizabeth Hampson, Elpida Tsonou, Chiara Pantarelli, Julia Y. Chu, Laraine Crossland, Hanneke Okkenhaug, Andrew J. Massey, David C. Hornigold, Heidi C. E. Welch, Stephen A. Chetwynd

Functions and mechanisms of the GPCR adaptor protein Norbin

Norbin (Neurochondrin, NCDN) is a highly conserved 79 kDa adaptor protein that was first identified more than a quarter of a century …

Stephen A. Chetwynd, Simon Andrews, Sarah Inglesfield, Christine Delon, Nicholas T. Ktistakis, Heidi C. E. Welch