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The Rac-GEF Tiam1 controls integrin-dependent neutrophil responses
textlessptextgreaterRac GTPases are required for neutrophil adhesion and migration, and for the neutrophil effector responses that kill …
Kirsti Hornigold, Martin J. Baker, Polly A. Machin, Stephen A. Chetwynd, Anna-Karin Johnsson, Chiara Pantarelli, Priota Islam, Melanie Stammers, Laraine Crossland, David Oxley, Hanneke Okkenhaug, Simon Walker, Rachael Walker, Anne Segonds-Pichon, Yoshinori Fukui, Angeliki Malliri, Heidi C. E. Welch
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The GPCR adaptor protein Norbin regulates S1PR1 trafficking and the morphology, cell cycle and survival of PC12 cells
Norbin is an adaptor protein that binds numerous G protein-coupled receptors (GPCRs), is highly expressed in neurons, and is essential …
Valdemar B. I. Johansen, Elizabeth Hampson, Elpida Tsonou, Chiara Pantarelli, Julia Y. Chu, Laraine Crossland, Hanneke Okkenhaug, Andrew J. Massey, David C. Hornigold, Heidi C. E. Welch, Stephen A. Chetwynd
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Functions and mechanisms of the GPCR adaptor protein Norbin
Norbin (Neurochondrin, NCDN) is a highly conserved 79 kDa adaptor protein that was first identified more than a quarter of a century …
Stephen A. Chetwynd, Simon Andrews, Sarah Inglesfield, Christine Delon, Nicholas T. Ktistakis, Heidi C. E. Welch
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Dock2 generates characteristic spatiotemporal patterns of Rac activity to regulate neutrophil polarisation, migration and phagocytosis
INTRODUCTION: Rac-GTPases and their Rac-GEF activators play important roles in neutrophil-mediated host defence. These proteins control …
Polly A. Machin, Anna-Karin E. Johnsson, Ellie J. Massey, Chiara Pantarelli, Stephen A. Chetwynd, Julia Y. Chu, Hanneke Okkenhaug, Anne Segonds-Pichon, Simon Walker, Angeliki Malliri, Yoshinori Fukui, Heidi C. E. Welch
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Age-related decline in the resistance of mice to bacterial infection and in LPS/TLR4 pathway-dependent neutrophil responses
Host defense against bacterial and fungal infections diminishes with age. In humans, impaired neutrophil responses are thought to …
Kirsti Hornigold, Julia Y. Chu, Stephen A. Chetwynd, Polly A. Machin, Laraine Crossland, Chiara Pantarelli, Karen E. Anderson, Phillip T. Hawkins, Anne Segonds-Pichon, David Oxley, Heidi C. E. Welch
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Behavioural immune landscapes of inflammation
Transcriptional and proteomic profiling of individual cells have revolutionized interpretation of biological phenomena by providing …
Georgiana Crainiciuc, Miguel Palomino-Segura, Miguel Molina-Moreno, Jon Sicilia, David G. Aragones, Jackson Liang Yao Li, Rodrigo Madurga, José M. Adrover, Alejandra Aroca-Crevillén, Sandra Martin-Salamanca, Alfonso Serrano Del Valle, Sandra D. Castillo, Heidi C. E. Welch, Oliver Soehnlein, Mariona Graupera, Fátima Sánchez-Cabo, Alexander Zarbock, Thomas E. Smithgall, Mauro Di Pilato, Thorsten R. Mempel, Pierre-Louis Tharaux, Santiago F. González, Angel Ayuso-Sacido, Lai Guan Ng, Gabriel F. Calvo, Iván González-Díaz, Fernando Díaz-De-María, Andrés Hidalgo
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Small-molecule inhibitors of P-Rex guanine-nucleotide exchange factors
P-Rex1 and P-Rex2 are guanine-nucleotide exchange factors (GEFs) that activate Rac small GTPases in response to the stimulation of G …
C. D. Lawson, K. Hornigold, D. Pan, I. Niewczas, S. Andrews, J. Clark, Hce Welch
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Optimizing metastatic-cascade-dependent Rac1 targeting in breast cancer: Guidance using optical window intravital FRET imaging
Assessing drug response within live native tissue provides increased fidelity with regards to optimizing efficacy while minimizing …
Alessia Floerchinger, Kendelle J. Murphy, Sharissa L. Latham, Sean C. Warren, Andrew T. McCulloch, Young-Kyung Lee, Janett Stoehr, Pauline Mélénec, Cris S. Guaman, Xanthe L. Metcalf, Victoria Lee, Anaiis Zaratzian, Andrew Da Silva, Michael Tayao, Sonia Rolo, Monica Phimmachanh, Ghazal Sultani, Laura McDonald, Susan M. Mason, Nicola Ferrari, Lisa M. Ooms, Anna-Karin E. Johnsson, Heather J. Spence, Michael F. Olson, Laura M. Machesky, Owen J. Sansom, Jennifer P. Morton, Christina A. Mitchell, Michael S. Samuel, David R. Croucher, Heidi C. E. Welch, Karen Blyth, C. Elizabeth Caldon, David Herrmann, Kurt I. Anderson, Paul Timpson, Max Nobis
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P-Rex1 Controls Sphingosine 1-Phosphate Receptor Signalling, Morphology, and Cell-Cycle Progression in Neuronal Cells
P-Rex1 is a guanine-nucleotide exchange factor (GEF) that activates Rac-type small G proteins in response to the stimulation of a range …
Elizabeth Hampson, Elpida Tsonou, Martin J. Baker, David C. Hornigold, Roderick E. Hubbard, Andrew Massey, Heidi C. E. Welch
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The GPCR adaptor protein norbin suppresses the neutrophil-mediated immunity of mice to pneumococcal infection
Streptococcal pneumonia is a worldwide health problem that kills ∼2 million people each year, particularly young children, the elderly, …
Chiara Pantarelli, Dingxin Pan, Stephen Chetwynd, Anne-Katrien Stark, Kirsti Hornigold, Polly Machin, Laraine Crossland, Simon J. Cleary, Martin J. Baker, Elizabeth Hampson, Anna Mandel, Anne Segonds-Pichon, Rachael Walker, Cornelis Van 'T Veer, Yanira Riffo-Vasquez, Klaus Okkenhaug, Simon Pitchford, Heidi C. E. Welch
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